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Because the brain becomes dependent on nicotine, a person who tries to stop using the drug will experience unpleasant symptoms of withdrawal. Physical symptoms like headaches, cramps, and difficulty sleeping can persist for three to five days. Mental symptoms of withdrawal, such as depression, irritability, and a strong desire to use nicotine, can last for weeks. Withdrawal makes it very hard for users to quit smoking or vaping.

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How Nicotine Impacts the Body and Mind